Acetaminophen is an internal analgesic available in over-the-counter (OTC) medicines that temporarily relieve minor aches and pains and reduce fevers. Acetaminophen is also available in prescription medicines combined with other ingredients, and on some prescription labels it may be abbreviated as APAP. It will never be abbreviated and will always say acetaminophen on Drug Facts labels.

Acetaminophen can be the only ingredient in oral pain relievers and fever reducers or it can be found in medicines that contain more than one active ingredient to treat migraines. Acetaminophen can also be found in medicines that treat occasional sleeplessness, the multiple symptoms of the common cold, and symptoms associated with menstruation. For individuals who cannot take an oral medicine, acetaminophen is available in single-ingredient rectal suppositories.

Acetaminophen is approved by the U.S. Food and Drug Administration (FDA) and is safe and effective when used according to label directions. Because so many medicines contain acetaminophen, it is important to check the label to see which medicines contain acetaminophen and to never take more than the maximum daily dose listed on the label. You should never take more than one medicine that contains acetaminophen at a time or use it for a longer period of time than what is recommended on the label. Taking too much acetaminophen can cause an overdose and may lead to liver damage.

If you ever have questions on your health or the health of a family member, talk to your healthcare provider.

KnowYourDose

Acetaminophen is one of the most common drug ingredients in America, found in more than 600 different medicines. The Know Your Dose campaign reminds you to follow four simple steps to use acetaminophen safely: 1) Always read and follow the medicine label; 2) Know if your medicines contain acetaminophen; 3) Never take two medicines with acetaminophen at the same time; and 4) Ask your healthcare provider or pharmacist if you have questions about dosing instructions or medicines that contain acetaminophen.

  • You are currently taking any other acetaminophen-containing prescription or OTC medicine. Acetaminophen may be written as APAP on prescription labels, but it is the same active ingredient. Taking too much acetaminophen can lead to an overdose and may cause liver damage.
  • You are allergic to acetaminophen.
  • Tamper-evident packaging features such as seals, locks, and films are not clear or seem broken.
  • You are currently using another medicine containing an internal analgesic active ingredient (e.g., aspirin, magnesium salicylate, naproxen sodium, ibuprofen, and ketoprofen).
  • You have liver disease.
  • You are taking the blood thinning drug warfarin.
  • You drink three or more alcoholic drinks a day.
  • You are pregnant or breastfeeding.
  • Your fever gets worse or lasts more than three days, or if your pain gets worse or lasts for more than 10 days.
  • New symptoms occur or redness or swelling is present.
  • You take too much. Immediately contact a healthcare provider or the poison control national helpline at 800.222.1222.
  • Acetaminophen-containing medicines are available in different dosage strengths. Do not give an OTC medicine containing acetaminophen to a child that is only intended for use in adults as this would provide more than the recommended dose and may cause liver damage.
  • Read the label for proper child dosing instructions. Contact a healthcare provider as directed.
  • For liquid medicines, only use the dosing device enclosed with the medicine.
  • Talk to a healthcare provider before giving acetaminophen to a child with liver disease.
  • Severe liver damage may occur if your child takes more than the maximum daily dosage in 24 hours or with other medicines containing acetaminophen.
  • If your child has a severe sore throat that lasts for more than two days, is accompanied or followed by high fever, headache, nausea, or vomiting, contact a healthcare provider immediately.
  • Pay attention to the concentration (or strength) of infants’ single-ingredient liquid acetaminophen when treating your child. The makers of infant single-ingredient liquid acetaminophen have changed the medicine from a highly concentrated dose to a less concentrated dose (80 mg/0.8 mL to 160 mg/5 mL). During this transition, old medicines could still be on store shelves and in your home. To avoid dosing errors, consumers, parents, and caregivers should carefully read the Drug Facts label on the package to identify the concentration of the liquid acetaminophen (in mg/mL), dosage, and directions for use. Parents and caregivers should ask a healthcare provider if they have any questions.
  • For information on dosing of acetaminophen-containing medicines, visit the American Academy of Pediatrics website.
  • Click here for more information on giving OTCs to children.