Clotrimazole is an antifungal that has different uses in over-the-counter (OTC) medicines. Depending on the dose and form, clotrimazole can be used to treat symptoms associated with skin fungus infections such as athlete’s foot, jock itch, and ringworm. Clotrimazole can also be used to treat vaginal yeast infections. Clotrimazole can be found in single-ingredient topical skin fungus medicines as well as in single-ingredient vaginal yeast infection products.

Clotrimazole is approved by the U.S. Food and Drug Administration (FDA) and is safe and effective when used according to the Drug Facts label directions. Clotrimazole-containing medicines that are labeled to treat athlete’s foot, jock itch, and ringworm are for external use only and should never be used to treat vaginal yeast infections.

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For Athlete’s Foot, Jock Itch, or Ring Worm

  • Irritation occurs.
  • There is no improvement of athlete’s foot or ringworm after four weeks of treatment.
  • There is no improvement of jock itch after two weeks of treatment.
  • You accidentally swallow the medicine. Immediately contact a healthcare provider or the poison control national helpline at 800.222.1222.
  • Do not use a topical skin fungus medicine containing clotrimazole on a child under the age of 2 unless you are under the advice and supervision of a healthcare provider.
  • Children should be supervised when using clotrimazole-containing skin fungus medicines.
  • Click here for more information on giving OTCs to children.

For Vaginal Yeast Infections

  • These products are for vaginal or external vulva use only. Read the educational pamphlet enclosed with the medicine for complete directions and information.
  • You should use the applicator enclosed with the medicine if one is provided.
  • You should not use tampons, douches, or spermicides while using a medicine containing clotrimazole.
  • Condoms or diaphragms may be damaged and fail to prevent pregnancy or sexually transmitted diseases.
  • You have vaginal itching and discomfort for the first time.
  • You have symptoms that returned within two months.
  • You are pregnant, could be pregnant, or are breastfeeding.
  • You have a serious underlying medical condition that may be causing your symptoms, such as diabetes or a weakened immune system.
  • You have never had a vaginal yeast infection diagnosed by a healthcare provider.
  • You have vulva itching that is not caused by a vaginal yeast infection.
  • You have a fever higher than 100° F; pain in the lower abdomen, back, or either shoulder; or a foul-smelling vaginal discharge. You should see a healthcare provider for treatment of these symptoms.
  • The product’s tube seal has been punctured or is not visible.
  • Your symptoms do not get better within three days or the infection lasts for more than seven days.
  • You develop a rash, fever, abdominal pain, or a foul-smelling vaginal discharge.
  • You accidentally swallow the medicine. Immediately contact a healthcare provider or the poison control national helpline at 800.222.1222.
  • Do not use a vaginal product containing clotrimazole on a child under the age of 12.