Famotidine is an acid-reducing active ingredient available in over-the-counter (OTC) medicines that relieve or prevent heartburn symptoms associated with acid indigestion and sour stomach. Famotidine is part of a group of acid reducers called Histamine-2 antagonists, or H2 blockers. It can be the only active ingredient in heartburn medicines that provide long-lasting relief of symptoms, or it can be found in medicines that provide both short- and longer-term symptom relief.

Famotidine is approved by the U.S. Food and Drug Administration (FDA) and is safe and effective when used according to the Drug Facts label. But if your heartburn symptoms continue or get worse while you are taking an OTC medicine containing famotidine, contact your healthcare provider. Chronic heartburn may be a sign of a more serious condition.

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  • You are allergic to famotidine or other acid reducers.
  • You have trouble or pain swallowing food, you are vomiting with blood, or you have bloody or black stools.
  • You have kidney disease, unless you are under the advice and supervision of a healthcare provider.
  • You are currently using another acid reducer.
  • You have had heartburn for more than three months.
  • Your heartburn is accompanied by lightheadedness, sweating, or dizziness.
  • You are experiencing chest or shoulder pain with shortness of breath; sweating; pain spreading to your arms, neck, or shoulders; or lightheadedness.
  • You have frequent chest pain, wheezing, unexplained weight loss, nausea or vomiting, or stomach pain.
  • You are pregnant or breastfeeding
  • Your heartburn continues or gets worse.
  • You need to take the medicine for more than 14 days.
  • You take too much. Immediately contact a healthcare provider or the poison control national helpline at 800.222.1222.
  • Talk to a healthcare provider before giving an OTC medicine containing famotidine to a child under the age of 12.
  • Click here for more information on giving OTCs to children.