Magnesium salicylate is an internal analgesic available in over-the-counter (OTC) medicines that temporarily relieve minor aches and pains. Magnesium salicylate is part of a group of pain relievers and fever reducers called nonsteroidal anti-inflammatory drugs (NSAIDs).

Magnesium salicylate can be found in single-ingredient oral pain relievers or in medicines that contain more than one active ingredient to treat symptoms associated with premenstrual and menstrual periods such as: water weight gain, bloating, fatigue, and minor aches and pains.

Magnesium salicylate is approved by the U.S. Food and Drug Administration (FDA) and is safe and effective when used according to the Drug Facts label. You should never take more magnesium salicylate or for a longer period of time than the label instructs unless directed by your healthcare provider. Magnesium salicylate may not be appropriate for everyone. Parents and other caregivers should never give a medicine containing magnesium salicylate to a child or teenager who has or is recovering from chicken pox or flu-like symptoms. When using magnesium salicylate, if changes in behavior with nausea and vomiting occur, consult a doctor because these symptoms could be an early sign of Reye’s syndrome, a rare but serious illness.

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  • You drink more than three or more alcoholic drinks a day.
  • You are currently using a medicine containing a prescription or nonprescription NSAID (e.g., aspirin, naproxen sodium, ibuprofen, or others).
  • You have stomach problems that last or come back, such as heartburn, upset stomach, or stomach pain; ulcers; or bleeding problems.
  • You have asthma.
  • You are taking a prescription blood thinner (anticoagulant), steroid drug, or a prescription medicine for gout, diabetes, or arthritis.
  • You have high blood pressure, heart disease, liver cirrhosis, or kidney disease.
  • You are taking a diuretic.
  • You are pregnant or breastfeeding. Women in the last three months of pregnancy are specifically told not to use aspirin or any other NSAID (e.g., aspirin, naproxen sodium, ibuprofen, or others) without a healthcare provider’s permission.
  • You are allergic to salicylates (including aspirin) or any other pain reliever/fever reducer.
  • You are a woman in the last three months of pregnancy unless your healthcare provider specifically tells you to. Problems in the unborn child or complications during delivery may occur.
  • Tamper-evident packaging features such as seals, locks, and films are not clear or seem broken.
  • An allergic reaction occurs. Seek medical help right away.
  • Your fever gets worse or lasts more than three days, or if your pain gets worse and lasts more than 10 days.
  • You have signs of stomach bleeding, such as if you feel faint, vomit blood, have stomach pain or upset that lasts or does not get better, or if you have bloody or black stools.
  • Redness or swelling is present in the painful area or if any new symptoms appear.
  • You hear ringing in your ears or you begin to lose your hearing.
  • You take too much. Immediately contact a healthcare provider or the poison control national helpline at 800.222.1222.
  • Do not give magnesium salicylate to a child under the age of 12 unless a healthcare provider tells you to.
  • Do not give an OTC medicine containing magnesium salicylate to a child or teenager with chicken pox or flu due to a rare illness (Reye’s syndrome) reported to be associated with both magnesium salicylate and aspirin.
  • Click here for more information on giving OTCs to children.