Orlistat is a weight loss aid available in over-the-counter (OTC) medicines that help promote weight loss in overweight adults when used in combination with a reduced-calorie and low-fat diet.

Orlistat is approved by the U.S. Food and Drug Administration (FDA) and is safe and effective when used according to the Drug Facts label. The active ingredient orlistat works by preventing the absorption of some of the fat you eat. Because orlistat can also reduce the absorption of some vitamins, it is important to take a multivitamin once a day while taking this medicine.


  • You are taking the blood thinning medicine warfarin.
  • You are taking a medicine for diabetes or thyroid disease.
  • You are taking other weight loss medicines.
  • You are pregnant or breastfeeding.
  • Severe or continuous abdominal pain occurs. This may be a sign of a serious medical condition.
  • You take too much. Immediately contact a healthcare provider or the poison control national helpline at 800.222.1222.